|Name||Ms. SELAM HAGOS|
|Organization or Institution||University of south Florida|
Chemical Investigation of Antarctic Sponges
University of South Florida
In terms of significant contributions of nature to the biomedical sciences, marine sponges have been an important source of potential drugs for diseases like cancer, infectious, and inflammatory diseases. Secondary metabolites isolated from sponges are structurally diverse and have shown interaction with important biological receptors, many of which have implications for human disease. In this project, several red/orange sponges collected over the years from different sites of Antarctica underwent Nuclear Magnetic Resonance (NMR) spectroscopy guided fractionation. Using ELSD (Evaporative Light Scattering Detector) and UV detectors, Normal phase MPLC (Medium Pressure Liquid Chromatography) followed in sequence by RP HPLC(Reverse Phase High-Pressure Liquid Chromatography) separations obtained several chemically interesting fractions and pure compounds. Structure elucidation of the pure compounds was performed using one-and-two-dimensional NMR. These pure compounds and future isolates will be subjected to bioassay against Zika virus, ESKAPE pathogens and Clostridium difficile.