In by admin

Name Miss Katherine White
Organization or Institution University of Florida
Presentation Type Poster
Topic Organic Chemistry

Synthesis of versatile allenyl malonates via the reductive enyne Cope rearrangement


Katherine E White, Sarah K Scott, and Alexander J Grenning

Author Institution(s)

University of Florida


Rearrangement of 1,5-enynes to generate allenes has potential utility in the synthesis of natural product frameworks, but previously low yields have limited the implementation of this transformation. Through development of a reductive enyne Cope rearrangement, functionalized allenyl malonates are now easily accessed from simple starting materials. These allenyl malonates serve as useful synthetic intermediates for further functionalization to access various polycyclic scaffolds commonly found in terpenoid natural products.