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Name Mr. Reece Johsnon
Organization or Institution Florida Gulf Coast University
Presentation Type Poster
Topic Organic Chemistry
Title

Green, Solid-Supported Catalyst for the Synthesis of Superior Cancer-Fighting Resveratrol Analogues

Author(s)

Reece Johnson, Noah Cyr, Daniel H. Paull

Author Institution(s)

Florida Gulf Coast University

Abstract

Green syntheses are an integral part of modern day cancer research. Our eco-friendly, “green” reactions involve the use of solid-supported catalysts that are recyclable. This allows for an easy synthesis of resveratrol analogues with high yield to minimal waste ratios. A multitude of resveratrol analogues have been synthesized and have been tested for their potential in anti-cancer activity within stem cells. Further research will provide extension to one-pot synthesis via a multitude of reactions such as Sonogashira and Suzuki for example. Our catalysts are based on ionic liquids (ILs) attached to solid support and bound to active palladium by N-heterocyclic carbenes (NHCs). The yields of specific reactions have increased; this has also enabled us to explore different types of reactions. The ILs and resveratrol analogues were characterized using NMR and GC-MS. The synthesis of the catalysts and the results of the anti-cancer activity of these analogues will be discussed.