Name | Ms. Ying He |
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Organization or Institution | University of South Florida |
Presentation Type | Poster |
Topic | Organic Chemistry |
Title | Precise Formation of concise G-Octamer for Construction of Noncovalent and Covalent “Molecular Cube” with enhanced stability |
Author(s) | Ying He, Yanbin Zhang, Xiaodong Shi |
Author Institution(s) | University of South Florida |
Abstract | Both non-covalent and covalent “molecular cube” was constructed through self-assembly of designated guanosine derivatives, which were characterized by X-ray, NMR and MS. The key design was the analysis of the key steric factors that control G-quartet stacking. With the introduction of 8-aryl and sterically hindered protecting group on ribose, interdigitation of sugar between G-quartet layers was prevented successfully and a concise, discrete self-assembled guanosine octamer was achieved with enhanced stability and unique property on Rb+ recognition. |