| Name | Mr. Peiye Liu |
|---|---|
| Organization or Institution | Department of Chemistry & Biochemistry, Florida State University |
| Presentation Type | Poster |
| Topic | Organic Chemistry |
| Title | Synthesis of 1-Cyanoalkynes and Their Ruthenium(II)-Catalyzed Cycloaddition with Organic Azides to Afford 4-Cyano-1,2,3-triazoles |
| Author(s) | Peiye Liu, Ronald J. Clark, and Lei Zhu |
| Author Institution(s) | Department of Chemistry and Biochemistry, Florida State University, 95 Chieftan Way, Tallahassee, FL 32306-4390 |
| Abstract | A new and convenient two-step sequence to prepare 4-cyano-1,2,3-triazoles from terminal alkynes and organic azides has been developed. This sequence involves Cu-mediated 1-cyanoalkyne formation via in-situ formed cyanogen, and Ru-catalysed regiospecific azide-alkyne cycloaddition. A new mechanistic proposal distinguishing from that the terminal alkynes adopt under the same reaction conditions is proposed. |
American Chemical Society - Florida Section
