|Name||Mr. Peiye Liu|
|Organization or Institution||Department of Chemistry & Biochemistry, Florida State University|
Synthesis of 1-Cyanoalkynes and Their Ruthenium(II)-Catalyzed Cycloaddition with Organic Azides to Afford 4-Cyano-1,2,3-triazoles
Peiye Liu, Ronald J. Clark, and Lei Zhu
Department of Chemistry and Biochemistry, Florida State University, 95 Chieftan Way, Tallahassee, FL 32306-4390
A new and convenient two-step sequence to prepare 4-cyano-1,2,3-triazoles from terminal alkynes and organic azides has been developed. This sequence involves Cu-mediated 1-cyanoalkyne formation via in-situ formed cyanogen, and Ru-catalysed regiospecific azide-alkyne cycloaddition. A new mechanistic proposal distinguishing from that the terminal alkynes adopt under the same reaction conditions is proposed.