|Organization or Institution||Florida International University|
SERS-based Screening Test for Synthetic Cannabinoids in Oral Fluid
Chiara Deriu1,2, MS; Irene Conticello1,3, MS; Bruce McCord1,2, PhD
1 Department of Chemistry and Biochemistry, Florida International University, Miami, FL, USA
Synthetic cannabinoids are new psychoactive substances (NPS’s) that represent a worldwide issue due to unknown toxicological effects and widespread use among the young population. Moreover, the rapidity by which these compounds are modified and introduced into the illegal market makes it difficult to detect them using standard screening methods, such as immunoassays. Cross-reactivity between different species, and false negative responses severely limit this approach. Surface Enhanced Raman Spectroscopy (SERS) has been shown by our research group to have great potential to solve these problems, by providing a sensitive and selective screening approach that yields fingerprint signals from xenobiotics at toxicological concentrations. This was achieved on benzodiazepines, both as standard solutions and in spiked urine matrices [1,2], and more recently, on standard solutions of synthetic cannabinoids .