|Name||Mr. Anthony Giacalone|
|Organization or Institution||University of South Florida|
Encapsulation of photoactive Ru(II) (2,2’-Bipyridine)2(Bio-Active molecules)2 within MOFs for novel drug delivery
Anthony G. Giacalone
Randy W. Larsen
University of South Florida
Metal Organic Frameworks (MOFs) are a class of porous materials composed of organic ligands linked through metal clusters (molecular building blocks or MBBs) that have an exceptional potential to serve as platforms for a wide array of applications including novel drug delivery. Drug delivery applications for MOFs are of increasing interest as these materials can contain a high weight percent of biologically active compounds within the large interior cavities while the relatively small pore sizes enable effective time release. Here we describe the development of a novel photodynamic therapy application of MOFs in which a Ru(II) (2,2’-Bipyridine)2(BAM)2 (BAM = Bio-Active Molecule) cluster is encapsulated within the cavities of the Zn-based polyhedral MOF, USF2. Exposure of the new materials to white light results in the photoejection of the BAM and subsequent egress to the bulk solvent through the exterior pores. Photoejectable molecules of interest are Acetonitrile (ACN), 4-Aminopyridine (4APY), γ- aminobutyric acid (GABA) and 4-Methylamino butyric acid hydrochloride (GABE).