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Name Mr. Teng Yuan
Organization or Institution University of South Florida
Presentation Type Poster
Topic Organic Chemistry
Title

Gold and Iron combined catalysis in directed aldol reaction

Author(s)

Teng Yuan, Xiaodong (Mike) Shi

Author Institution(s)

University of South Florida

Abstract

Beta-hydroxy ketone skeleton is very common in natural products. Aldol reaction is an efficient way to synthesise this kind of structure. However, due to the isomerization of ketone and enal, conversional aldol reaction suffer from the side reaction and poor regioselectivity. Mukaiya aldol reaction realised directed aldol reaction despite 1 equiv silyl reagent used. Here we report our method to access this type of compound by Gold-Iron synergic catalysis.