|Name||Mr. Teng Yuan|
|Organization or Institution||University of South Florida|
Gold and Iron combined catalysis in directed aldol reaction
Teng Yuan, Xiaodong (Mike) Shi
University of South Florida
Beta-hydroxy ketone skeleton is very common in natural products. Aldol reaction is an efficient way to synthesise this kind of structure. However, due to the isomerization of ketone and enal, conversional aldol reaction suffer from the side reaction and poor regioselectivity. Mukaiya aldol reaction realised directed aldol reaction despite 1 equiv silyl reagent used. Here we report our method to access this type of compound by Gold-Iron synergic catalysis.